These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Morphometry of superficial glomeruli in acute hypertension in the rat.
    Author: Olivetti G, Giacomelli F, Wiener J.
    Journal: Kidney Int; 1985 Jan; 27(1):31-8. PubMed ID: 3981871.
    Abstract:
    Pressor doses of angiotensin II (AII) were infused intravenously in Munich-Wistar rats to study the effects of acute hypertension on the structural components of the superficial renal corpuscles and urinary protein excretion. All administration raises arterial blood pressure by 38% and increases 13-fold the normal rate of urinary excretion of proteins that contain albumin and IgG. Morphometric analysis of the quantitative characteristics of the glomerular capillaries reveals a 24% increase in the mean cross-sectional area of the capillary profiles and a 33% expansion of the capillary luminal volume. The amount of extracellular material present in the mesangium is also increased by 76%. The surface area of basement membrane available for ultrafiltration remains constant. However, the length density and the total length of the filtration slit diaphragms are reduced by 35 and 24%, respectively. Thus, the major findings of this investigation are as follows: The presence of IgG in the urine suggests a size defect in the glomerular filter with AII-induced hypertension; the dilatation of capillary loops may result in mechanical stretching of the basement membrane, altering the size-selective properties of the glomerular filter in acute hypertension; and the reduced pore area of the filtration slit diaphragms implies a lower hydraulic conductivity of the glomerular filter that may be responsible for the decreased glomerular capillary ultrafiltration coefficient present in this model of hypertension.
    [Abstract] [Full Text] [Related] [New Search]