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  • Title: Changes in serum cathepsin B-like activity in patients with colorectal cancer.
    Author: Dufek V, Jirásek V, Král V, Matous B, Drazná E.
    Journal: Neoplasma; 1985; 32(1):51-4. PubMed ID: 3982561.
    Abstract:
    Cathepsin B-like activity (CB-like) was estimated in sera of 30 male patients with colorectal cancer (n = 20), benign polyps of the rectum (n = 10) and in sera of control subjects (n = 50). Both total and residual activities of the enzyme in colorectal cancer patients showed a significant elevation in comparison with control subjects and patients with benign polyps. In the course of antitumor therapy a decline in catheptic activity was observed when a reduction in the volume of tumor tissue was present. On the other hand, an increment in CB-like activity was observed when antitumor therapy had no effects or tumor relapse was present.
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