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  • Title: Differential effect of cimetidine on serum concentrations of carbamazepine and phenytoin.
    Author: Levine M, Jones MW, Sheppard I.
    Journal: Neurology; 1985 Apr; 35(4):562-5. PubMed ID: 3982643.
    Abstract:
    Cimetidine is an inhibitor of drug metabolism. We studied the effects of cimetidine (1,200 mg/d) on steady-state serum concentrations of carbamazepine and phenytoin in 11 epileptic volunteers. The mean serum carbamazepine concentration was unchanged after 7 days of cimetidine treatment. Five subjects were taking phenytoin concurrently; their mean serum phenytoin concentration was significantly increased after 7 and 10 days of cimetidine treatment and returned to baseline 2 weeks after cimetidine was discontinued. Cimetidine apparently inhibits the clearance of phenytoin but not of carbamazepine in adults on chronic therapy.
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