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  • Title: Morphological study on the human developing vitreous collagen fibrils and persistent hyperplastic primary vitreous.
    Author: Akiya S, Uemura Y, Azuma N.
    Journal: Ophthalmic Res; 1985; 17(1):60-4. PubMed ID: 3982784.
    Abstract:
    The human primary vitreous fibrils were similar to the secondary vitreous fibrils on electron microscopic observation. On the other hand, the intravitreal strand in a persistent hyperplastic primary vitreous (PHPV) contained large numbers of collagenous fibrils with 40-50 nm diameters and about 65 nm cross-striation periodicity. Besides these, other types of noncross-striated fibrils, ranging in diameter from 10 to 30 nm were observed in the circumferential region of the intravitreal strand. Moreover, there was complete morphological continuation between the intravitreal strand and the optic disc. Their histochemical properties were very likely collagenous and in part glial. Although the results are based only on 1 case of PHPV, present observations showed that components of the intravitreal strand of PHPV considerably differed from the primary vitreous.
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