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  • Title: [In vivo activity of drug-metabolizing enzymes in various pathological conditions].
    Author: Krakovskiĭ ME, Ashirmetov AKh.
    Journal: Vopr Med Khim; 1985; 31(1):76-9. PubMed ID: 3984279.
    Abstract:
    Activity of enzymes, metabolizing drugs, was studied in acute kidney insufficiency and acute purulent peritonitis of rabbits using antipyrine test. In these pathological states the antipyrine half-life was increased and clearance was decreased, thus demonstrating the inhibition of drug-metabolizing enzymes. The data obtained suggest that the antipyrine test may exhibit the rate of drug metabolism in pathological conditions.
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