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  • Title: [Effect of diazepam on the formation and reproduction of conditioned cortical reactions in man].
    Author: Kostandov EA, Arzumanov IuL, Tal'tse MF.
    Journal: Zh Vyssh Nerv Deiat Im I P Pavlova; 1985; 35(1):52-9. PubMed ID: 3984510.
    Abstract:
    Intramuscular injections of seduxen (10 mg), a benzodiasepin drug, with expressed tranquilizing and alarm suppressing effects, were used with the aim of experimental testing of a hypothesis on the neural mechanism of conditioned changes of the P300 wave. Under the action of seduxen no temporary connections could be formed between a perceived nonverbal visual stimulus and a unrecognized emotional word. The seduxen did not suppress the conditioned cortical reaction acquired due to combination of nonverbal stimulus with unrecognized emotional word. The suggestion is made that the necessary condition of temporary connection elaboration by means of a unrecognized verbal stimulus is the implication of the limbic structures where negative emotional reactions are integrated.
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