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  • Title: 15(S)-15-methyl-prostaglandin F2 alpha used for induction of delivery in the case of intra-uterine fetal death.
    Author: Osler M, Lange AP, Moth I, Thomsen Pedersen G, Westergaard JG.
    Journal: Acta Obstet Gynecol Scand; 1985; 64(2):131-2. PubMed ID: 3984689.
    Abstract:
    102 pregnant women with intra-uterine fetal death after the 12th week of gestation were treated with 15(S)-15-methyl-prostaglandin F2 alpha intramuscularly with doses of 125-250 micrograms at 2-3 hourly intervals. In all cases abortion or delivery was completed within 30 hours. The average time in primigravidae was 9 hours 43 minutes, and in multigravidae 9 hours and 59 minutes. In approximately two-thirds of the patients, mild or moderate gastrointestinal side effects were recorded in spite of prophylactic treatment with Retardin or Loperamide + Diphenoxylate. The therapy was found to be effective, easy to administer and the side effects acceptable. No serious side effects were recorded.
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