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  • Title: Clonazepam and diltiazem both inhibit sodium-calcium exchange of mitochondria, but only diltiazem inhibits the slow action potentials of cardiac muscles.
    Author: Matlib MA, Doane JD, Sperelakis N, Riccippo-Neto F.
    Journal: Biochem Biophys Res Commun; 1985 Apr 16; 128(1):290-6. PubMed ID: 3985971.
    Abstract:
    Clonazepam, up to concentrations of 5 x 10(-5) M produced only 15% inhibition of contraction without effecting isoproterenol-induced slow action potentials (APs) of guinea pig papillary muscles. On the other hand, 10(-6) M diltiazem completely inhibited both slow APs and contractions. Both clonazepam and diltiazem inhibited Na+-induced Ca2+ release from isolated mitochondria. The half-maximum effect of clonazepam and diltiazem occurred at 7 and 8 x 10(-6) M respectively. The results suggest that clonazepam more specifically inhibits the Na+-induced Ca2+ release process of mitochondria.
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