These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A pharmacological analysis of the responses of the gastrointestinal smooth muscle of the bat to transmural and periarterial nerve stimulation.
    Author: Cole OF, Marquis VO.
    Journal: Br J Pharmacol; 1985 Mar; 84(3):587-93. PubMed ID: 3986428.
    Abstract:
    A comparative study of the responses of the gastrointestinal tract of the guinea-pig and of the fruit-eating bat Eidolon helvum to transmural nerve stimulation (TNS) was made. The stomach and rectum of the guinea-pig, the bat and the guinea-pig ileum contracted in response to TNS. These contractions were cholinergic in nature because atropine blocked and physostigmine potentiated them. Tetrodotoxin reversibly abolished these contractions suggesting that they were nerve-mediated. The bat isolated ileum usually responded to TNS with mixed motor and inhibitory components. In some cases, there were only motor or inhibitory components. The motor component was abolished by atropine and potentiated by physostigmine. However, the inhibitory component was non-adrenergic and non-cholinergic (NANC). Tetrodotoxin abolished the motor component without influencing the inhibitory components. Periarterial nerve stimulation of the bat ileum produced a relaxation that was blocked by bretylium, propranolol, phentolamine, reserpine and tetrodotoxin. It is concluded that the bat gastrointestinal smooth muscle, like the guinea-pig, has cholinergic excitatory innervation; however, the bat ileum has both a cholinergic excitatory innervation and a nonadrenergic and non-cholinergic inhibitory component.
    [Abstract] [Full Text] [Related] [New Search]