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  • Title: Met-enkephalin-Arg6-Gly7-Leu8 in the organ of Corti: high performance liquid chromatography and immunoelectron microscopy.
    Author: Eybalin M, Cupo A, Pujol R.
    Journal: Brain Res; 1985 Apr 08; 331(2):389-95. PubMed ID: 3986578.
    Abstract:
    The opioid octapeptide Met-enkephalin-Arg6-Gly7-Leu8 (MERGL) was identified and quantified in the guinea pig cochlea using high performance liquid chromatography and a specific radioimmunoassay. The presence of MERGL immunostaining in efferent endings (coming from the brainstem) within the inner spiral bundle and the tunnel spiral bundle was demonstrated using a pre-embedding immunoelectronmicroscopic technique. Axo-dendritic synapses were observed between the MERGL immunostained varicosities and auditory dendrites. It is hypothesized that MERGL could act, together with Met-enkephalin and other pro-enkephalin A-related peptides, as an efferent neuromodulator or neurotransmitter in the organ of Corti.
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