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  • Title: Effect of fusaric acid (a dopamine beta-hydroxylase inhibitor) on phaeochromocytoma.
    Author: Nagasaka A, Hara I, Imai Y, Uchikawa T, Yamauchi K, Suzuki S, Takatsuki K, Tomita A, Niinomi M, Nakagawa H.
    Journal: Clin Endocrinol (Oxf); 1985 Apr; 22(4):437-44. PubMed ID: 3987067.
    Abstract:
    Fusaric acid, an inhibitor of dopamine beta-hydroxylase, which converts dopamine to noradrenaline, lowered the blood pressure and induced a subjective improvement in patients with phaeochromocytoma. These effects may be due either to an impairment of catecholamine biosynthesis or to a direct action on the blood vessels. The use of this drug in the treatment of patients with inoperable malignant phaeochromocytoma or neuroblastoma may improve symptoms and prolong survival.
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