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  • Title: Synthesis of a nonacosapeptide (beta-fragment) corresponding to the N-terminal sequence 1-29 of human liver metallothionein II and its heavy metal-binding properties.
    Author: Okada Y, Ohta N, Yagyu M, Min KS, Onosaka S, Tanaka K.
    Journal: FEBS Lett; 1985 Apr 22; 183(2):375-8. PubMed ID: 3987895.
    Abstract:
    A nonacosapeptide (beta-fragment) corresponding to the N-terminal sequence 1-29 of human liver metallothionein II was synthesized by the fragment condensation method. The Cd-binding ability of the beta-fragment was much stronger than that of cysteine as thionein and synthetic alpha-fragment corresponding to the C-terminal sequence 30-61 of human liver metallothionein II. Both the alpha- and beta-fragments bound preferentially to Cu ions rather than Cd ions.
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