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  • Title: Influence of primary prostaglandins, prostacyclin and arachidonic acid on mesenteric hemodynamics in the pig.
    Author: Houvenaghel A, Schrauwen E, Wechsung L.
    Journal: Prostaglandins Med; 1979 Feb; 2(2):83-95. PubMed ID: 398986.
    Abstract:
    In anesthetized young pigs the influence of intraarterial infusion of prostaglandin E2, prostacyclin, prostaglandin F2 alpha, and arachidonic acid on mesenteric vascular resistance was studied. Infusion of PGE2 and prostacyclin induced a dose-dependent direct decrease in resistance. Infusion of PGF2 alpha resulted in a dose-dependent difference in response. Infusion of lower doses provoked a decrease in mesenteric vascular resistance, whereas infusion of higher doses resulted in an increase. Lower doses of arachidonic acid induced a gradual decrease in resistance, while higher doses provoked biphasic or triphasic responses. After previous blockade of the PG synthetase and lipoxygenase pathways with indomethacin and ETA, arachidonic acid only provoked a decrease in vascular resistance. The resultssuggest a possible role of prostaglandins and their precursors in autoregulation of mesenteric blood flow in the pig.
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