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  • Title: gamma-Aminobutyric acid enables synaptogenesis in the intact superior cervical ganglion of the adult rat.
    Author: Dames W, Joó F, Fehér O, Toldi J, Wolff JR.
    Journal: Neurosci Lett; 1985 Mar 15; 54(2-3):159-64. PubMed ID: 3991056.
    Abstract:
    Local gamma-aminobutyric acid (GABA) application into the intact superior cervical ganglion (SCG) of the adult rat allows active innervation of a surgically implanted hypoglossal nerve in addition to the normal nerve supply of the ganglion. In GABA-treated SCG of the adult rat, action potentials could be obtained on stimulation of both the preganglionic nerve trunk and the implanted hypoglossal nerve. Both action potentials were reversibly sensitive to hexamethonium bromide indicating new cholinergic synapses established between axons in the hypoglossal nerve and principal sympathetic neurons. If GABA treatment of the ganglion was omitted, the double innervation did not develop after hypoglossal nerve implantation.
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