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  • Title: Extracellular distribution of radiolabel obscures specific binding of diethylstilbestrol in mouse skeletal muscle.
    Author: Gruber B, Blix PM, Cohen L.
    Journal: Res Commun Chem Pathol Pharmacol; 1985 Mar; 47(3):445-8. PubMed ID: 3992019.
    Abstract:
    The extracellular distribution of 3H-diethylstilbestrol (3H-DES) in mouse skeletal muscle was assessed following intraperitoneal injection. Total muscle extracellular space was measured with 14C-inulin, and the vascular space with 125I-albumin. A significant difference in the distribution of native 3H-DES and its metabolites in muscle and blood was found. This could only be explained if these compounds distributed with the albumin space and not the inulin space.
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