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  • Title: Accelerated recovery of ischemic canine myocardium induced by AMP. Preliminary report.
    Author: Sami HM, Koke JR, Bittar N.
    Journal: Adv Myocardiol; 1985; 6():483-90. PubMed ID: 3992046.
    Abstract:
    Experiments were conducted on 18 dogs using an in situ blood-perfused canine heart model. Intracoronary infusion of AMP resulted in increased ATP and total adenine nucleotide levels. On reperfusion following a 15-min period of ischemia, ATP and total adenine nucleotide levels were significantly higher than control. Most important, contractile function recovered more rapidly in the AMP-treated dogs. It is therefore concluded that the delayed functional recovery noted after periods of ischemia is likely to be a direct result of delayed ATP resynthesis.
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