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  • Title: Evaluation of a topical treatment, alone and in combination with a detergent, for generalized demodicosis.
    Author: Folz SD, Kratzer DD, Nowakowski LH, Conklin RD, Rector DL.
    Journal: Vet Parasitol; 1985 Jan; 17(2):165-72. PubMed ID: 3992870.
    Abstract:
    Thirty dogs (20 treated, 10 controls) with naturally-acquired generalized demodicosis were utilized to evaluate the bio-activity and safety of a liquid concentrate formulation of amitraz, with or without the addition of a nonionic detergent. The detergent was added to the treatment mixture to enhance wetting and thereby reduce the number of treatments required to return diseased animals to a normal state. Three--six miticide treatments were topically applied to dogs at 14-day intervals, at a concentration of 250 parts per million active drug. The liquid concentrate with or without detergent, was equally effective and safe as a dermatotherapy for demodicosis; addition of the nonionic detergent grossly improved the wetting characteristics of the treatment mixture; however, it did not alter the biological activity or the safety of the therapy.
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