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  • Title: [Inhibition of NDV replication by theophylline].
    Author: Neĭcheva I, Vasileva L.
    Journal: Vet Med Nauki; 1985; 22(3):32-6. PubMed ID: 3992932.
    Abstract:
    Theophylline is said to produce an inhibiting effect on the replication of the Newcastle disease virus in chick embryo fibroblast cultures when used in conc. of 1 mM. When the cultures are treated with theophylline 24 hours prior to their infection or following one-hour adsorption the virus titer is lowered in the process of replication by about 2 lg as against the titer when the virus is replicated in theophylline-free cultures. The inhibiting effect consists in blocking or arresting the production of mature virions.
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