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  • Title: Indomethacin therapy for hypertrophic pulmonary osteoarthropathy in patients with bronchogenic carcinoma.
    Author: Leung FW, Williams AJ, Fan P.
    Journal: West J Med; 1985 Mar; 142(3):345-7. PubMed ID: 3993010.
    Abstract:
    Hypertrophic pulmonary osteoarthropathy (HPO) is a disabling complication of lung cancer often requiring thoracotomy with vagotomy for control of pain. This condition was confirmed by scintigraphy in six consecutive patients with biopsy-proved lung cancer. All had characteristic bone and joint pain unresponsive to a variety of analgesics. Treatment with indomethacin gave dramatic relief of pain within 72 hours in all six. Consideration should be given to instituting a controlled trial to establish the efficacy of indomethacin for the treatment of HPO.
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