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  • Title: [Clinical effectiveness of pipemidic acid on gonorrhoeal urethritis].
    Author: Yasumoto R, Morikawa Y, Horii A, Kawakita J, Kobayakawa H, Wada S, Sakamoto W, Ozaki Y, Nishijima T.
    Journal: Hinyokika Kiyo; 1985 Jan; 31(1):193-6. PubMed ID: 3993494.
    Abstract:
    Twenty cases of gonorrhoeal urethritis were orally treated with pipemidic acid (PPA). The results are as follows. The clinical effect of PPA was excellent in 9 cases and good in 6 cases, the efficacy rate being 75%. The usefulness of PPA was satisfactory in 12 cases (60%). No side effects were observed. The minimal inhibitory concentrations against 14 isolated Neisseria gonorrhoeal strains ranged from 0.78 to 3.13 micrograms/ml with a median value of 1.56 micrograms/ml. A beta-lactamase-producing strain was observed among the 14 strains and the case infected by this strain was successfully treated with PPA. These results indicate that PPA is a useful drug for the treatment of gonorrhoeal urethritis.
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