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  • Title: Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits.
    Author: Willis AL, Nagel B, Churchill V, Whyte MA, Smith DL, Mahmud I, Puppione DL.
    Journal: Arteriosclerosis; 1985; 5(3):250-5. PubMed ID: 3994582.
    Abstract:
    Dutch-belted rabbits fed a 2% cholesterol diet for 8 weeks developed atherosclerotic lesions that covered 37.2% +/- 3.5% of the aortic luminal surface. In samples of aortic arch, accumulation of cholesterol and triglyceride was also observed. Oral administration of nicardipine or nifedipine at dosages of 40 mg/kg twice daily for 8 weeks reduced plaque area by 49.2% and 58.7%, respectively. Nicardipine and nifedipine reduced cholesterol accumulation in the aortic arch by 74.5% and 69%, respectively. Triglyceride accumulation was totally abolished. Neither drug significantly altered cholesterol concentration of plasma low density lipoprotein or high density lipoprotein, although nicardipine produced a 42% reduction in cholesterol concentration of the d less than 1.006 g/ml fraction. The above results suggest potential therapeutic utility of nicardipine in atherosclerosis.
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