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  • Title: Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats.
    Author: Deacon R, Perry J, Lumb M, Chanarin I.
    Journal: Biochem J; 1985 Apr 01; 227(1):67-71. PubMed ID: 3994693.
    Abstract:
    N2O oxidizes and inactivates cob[I]alamin, and animals exposed in this way serve as models for cobalamin 'deficiency'. Such animals show a fall in activity of glycinamide ribotide transformylase and a rise in that of 5-amino-4-imidazolecarboxamide ribotide transformylase. The fall in glycinamide ribotide transformylase activity was prevented by parenteral 5'-methylthioadenosine derived from methionine. Methylthioadenosine in turn is converted into formate. Activity of glycinamide ribotide transformylase recovers after 7 days despite continued N2O inhalation, and this is probably related to restoration of methionine synthesis by induction of betaine:homocysteine transmethylase.
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