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  • Title: Hemoglobin M: effect of the proximal or distal histidine replacement on circular dichroism in the visible region.
    Author: Nagai M, Takama S, Yoneyama Y.
    Journal: Biochem Biophys Res Commun; 1985 Apr 30; 128(2):689-94. PubMed ID: 3994720.
    Abstract:
    To examine the effects of a replacement of the proximal or the distal histidine on the structure of hemoglobin (Hb), absorption and circular dichroic (CD) spectra of five species of Hbs M in the visible region were measured. Four Hbs M had a characteristic but a similar absorption spectrum upon amino acid substitution, however, the proximal histidine replaced Hbs M (Hb M Iwate and Hb M Hyde Park) showed considerably different CD spectra from those of the distal histidine replaced ones (Hb M Boston and Hb M Saskatoon). The former exhibited large positive CD but the latter gave a complex CD spectrum with positive and negative extrema. On the other hand, absorption and CD spectra of Hb M Milwaukee did not changed very much from those of Hb A.
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