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  • Title: Sulfation in isolated kidney tubule fragments of rats. Dependence on inorganic sulfate.
    Author: Chen QY, Schwarz LR.
    Journal: Biochem Pharmacol; 1985 May 01; 34(9):1363-6. PubMed ID: 3994751.
    Abstract:
    Uptake and conjugation of sulfate was studied in isolated kidney tubule fragments of rats: Sulfate is rapidly taken up, and maximal cellular concentrations are attained after 5-10 min; intracellular steady-state levels depend on the sulfate concentrations of the medium and attain a maximal value at 2 mM. At 1 mM sulfate in the medium the ratio of intracellular/extracellular concentrations of the inorganic anion amount to about 0.25. Formation of 7-hydroxycoumarin sulfate increases almost linearly up to an extracellular sulfate concentration of 500 microM. Thereafter, rates of sulfation increase more slowly and maximal sulfation rates are attained at 2 mM sulfate. The data indicate that sulfation of 7-hydroxycoumarin proceeds at almost maximal rates in kidney tubule fragments at physiological serum sulfate concentrations.
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