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  • Title: Distribution of polyamines in human epidermis.
    Author: Baze PE, Milano G, Verrando P, Renee N, Ortonne JP.
    Journal: Br J Dermatol; 1985 Apr; 112(4):393-6. PubMed ID: 3994918.
    Abstract:
    Consecutive sections through the epidermis were cut parallel to its surface, and the polyamine (PA) concentration in each section was measured by liquid chromatography. There was a constant decrease in PA concentration (expressed as nmol/mg DNA) from the deepest layer to the more superficial layers. Putrescine showed the greatest increase (+83%) (P less than 0.02). The elevations of spermidine and spermine levels were less marked, respectively +30% (P less than 0.05) and +27% (NS). Proliferating cells in the basal layer possess high polyamine levels and as they mature in the superficial layers their polyamine content decreases.
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