These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies on activation of benzo[a]pyrene for inhibition of interferon induction.
    Author: DeLor DK, Sonnenfeld G.
    Journal: Environ Res; 1985 Jun; 37(1):205-11. PubMed ID: 3996338.
    Abstract:
    The induction of interferon-alpha/beta (IFN-alpha/beta) by polyriboinosinic-polyribocytidylic acid (PIC) was inhibited when mouse embryo fibroblasts were pretreated with the carcinogen, benzo[a]pyrene (BP). When BP was added to the cell cultures simultaneously with reduced glutathione (GSH) or beta-naphthoflavone (B-NF), followed 24 hr later by the IFN-alpha/beta inducer, the inhibitory effects of BP on IFN-alpha/beta induction were abrogated. GSH and B-NF both interfere with the activation of BP to its ultimate carcinogenic form. These results suggest that BP must be metabolically activated to inhibit the induction of IFN-alpha/beta.
    [Abstract] [Full Text] [Related] [New Search]