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  • Title: Cell cycle regulation in mammalian cells: hormones and commitment to DNA synthesis.
    Author: Armelin HA, Armelin MC.
    Journal: Arch Biol Med Exp; 1979 Oct; 12(3):319-24. PubMed ID: 399721.
    Abstract:
    The growth regulation of cultured mouse fibroblasts and functional adrenal cells was studied. Variants of mutants from these cell lines were obtained. The effects of classical hormones (insulin, hydrocortisone and adrenocorticotropin) and of growth factors (EGF and PF) were analysed. These hormones stimulate or inhibit the entry of cells into S phase. However G1 cells become irreversibly committed to DNA synthesis 5 hours before entering S phase.
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