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  • Title: [Testing the loss of efficacy (tachyphylaxis) during external steroid application].
    Author: Koch EM, Jurgovsky E.
    Journal: Hautarzt; 1985 Mar; 36(3):146-9. PubMed ID: 3997512.
    Abstract:
    The steroids fluprednylidene-21-acetate (FA) and betamethasone-17-valerate (BV) were tested in comparison to their inactive bases for loss of activity (tachyphylaxis) after 2 weeks of application. In the croton oil test, both steroids produced equal inhibition of the pustular inflammatory reaction. The vasoconstriction test after 14 days of use revealed a clear decrease in the blanching reaction - which was, however, not statistically significant in the case of BV.
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