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  • Title: The photodeactivation of hedamycin, an antitumor antibiotic of the pluramycin type.
    Author: Fredenhagen A, Séquin U.
    Journal: J Antibiot (Tokyo); 1985 Feb; 38(2):236-41. PubMed ID: 3997668.
    Abstract:
    The cytotoxicities of hedamycin and photohedamycin A as well as of kidamycin and isokidamycin were determined using HeLa cell cultures. Photohedamycin A proved to be 15 times less cytotoxic than hedamycin thus explaining the loss of biological activity observed for solutions of hedamycin left in daylight. The fact that photohedamycin A is less active than hedamycin, and isokidamycin less than kidamycin points to the important role the rings E and F play in the biological activity of hedamycin and kidamycin.
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