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  • Title: Plasma determination of 3-methylclonazepam by capillary gas chromatography.
    Author: Coassolo P, Aubert C, Cano JP.
    Journal: J Chromatogr; 1985 Mar 22; 338(2):347-55. PubMed ID: 3998022.
    Abstract:
    A capillary gas-liquid chromatographic method for the determination of 3-methylclonazepam in plasma was developed. This method involved a single extraction by butyl acetate followed by analysis of the organic extract on a CP-Sil 5 glass capillary column with detection by electron capture. The detection limit was about 0.1 ng/ml, and the inter- and intra-assay precision did not exceed 8% for the concentration range 0.1-6.0 ng/ml. Specificity towards some of the possible metabolites in human plasma was demonstrated. This method was used for the measurement of the pharmacokinetic parameters of 3-methylclonazepam in healthy volunteers after a single intravenous administration of 1 mg, and oral administrations of 1 and 4 mg.
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