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  • Title: Mutagenicity of organic extracts from Canadian drinking water in the Salmonella/mammalian-microsome assay.
    Author: Nestmann ER, LeBel GL, Williams DT, Kowbel DJ.
    Journal: Environ Mutagen; 1979; 1(4):337-45. PubMed ID: 399917.
    Abstract:
    Organic extracts of chlorinated Ontario drinking water samples have been found to induce mutation and lethality in the Salmonella/mammalian-microsome histadine reversion assay. Collections of water were made at water treatment plants in five municipalities in June 1978. To determine the reproducibility of the positive mutagenic effects found, a second sampling at the same plants was performed in September 1978. Preparation of extracts involved passing 200 liter samples through XAD-2 resin columns which were eluted with a mixture of hexane and acetone, and the eluent was evaporated to dryness. For those extracts with sufficient organic matter, dose-related increases in mutagenicity were observed. Extracts of untreated water from a river and a well were weakly mutagenic.
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