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  • Title: Effect of d-nicotine on the l-nicotine-induced increase in gastric acid secretion in rats.
    Author: Nagata M, Ishikawa T, Osumi Y.
    Journal: Jpn J Pharmacol; 1985 Feb; 37(2):215-7. PubMed ID: 3999475.
    Abstract:
    d-Nicotine (1000 micrograms) applied into the cerebral ventricle of urethane anesthetized rats increased gastric acid secretion. When 50 micrograms of d-nicotine was concomitantly administered with 5 micrograms of 1-nicotine, the 1-nicotine-induced increases in gastric secretion was blocked. The appearance of convulsion induced by I-nicotine in mice was also inhibited by pretreatment with d-nicotine. These results suggest that d-nicotine has agonistic and antagonistic actions to I-nicotine in the central nervous system and that its agonistic potency varies with preparations.
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