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  • Title: G0 chromosomal radiosensitivity in ataxia telangiectasia lymphocytes.
    Author: Bender MA, Rary JM, Kale RP.
    Journal: Mutat Res; 1985; 150(1-2):277-82. PubMed ID: 4000160.
    Abstract:
    Contrary to an earlier report, peripheral lymphocytes from 4 AT patients were not found to exhibit higher yields of unequivocal chromosome type aberrations following irradiation in the G0 phase of the cell cycle, providing that only first post-irradiation metaphases were included in the samples (ensured by 5-bromodeoxyuridine (BrdU) incorporation and differential fluorescence or Giemsa staining). We were able, however, to confirm the earlier-reported increase in chromatid-type aberrations in the G0-irradiated cells. AT lymphocytes were found to experience more cell-cycle delay following G0 irradiation than normal cells. These observations appear consistent with the damaged base excision DNA-repair defect reported for AT cells.
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