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  • Title: Ristocetin-induced platelet agglutination in four Chinese patients with Glanzmann's thrombasthenia.
    Author: Joyce RP, Ho FC, Hui PK, Wong HW, Lai MP.
    Journal: Pathology; 1985 Jan; 17(1):71-4. PubMed ID: 4000715.
    Abstract:
    We studied the degree of Ristocetin-induced platelet agglutination in 4 Chinese patients with Glanzmann's thrombasthenia. At Ristocetin concentrations of 1.2-2.0 mg/ml (final concentration) variable, abnormal responses were observed. The most notable feature in 3 of 4 patients studied was the phenomenon of dose dependent, cyclic platelet agglutination-disagglutination. However, this phenomenon could be reproduced in only one of the 2 patients who were investigated on 2 separate occasions. Variable, but often characteristic responses of thrombasthenic platelets to different concentrations of Ristocetin are a useful additional diagnostic marker for this disease.
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