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  • Title: [Temporal aspects of the function of the renin-angiotensin-aldosterone system. Contribution to the methodological standardization of explorative test (author's transl)].
    Author: Cugini P, Mancini A, Meucci T, Manconi R, Scavo D.
    Journal: Ann Ist Super Sanita; 1979; 15(2):179-96. PubMed ID: 400073.
    Abstract:
    The purpose of this study is to throw further light on the problem of the methodological standardization in the study of the renin-angiotensin-aldosterone system (RAAS). Thus, in 10 normal volunteers and 33 patients with moderate, recent and uncomplicated essential hypertension, divided into the subtypes with normal, high and low renin, it has been performed a timing analysis of the behaviour of plasma renin (PRA) and aldosterone (PA). PRA and PA were measured by radioimmunological methods in blood samples simultaneously collected in steady state conditions (study of circadian rhythmicity) and during the course of manipulative tests (orthostatism, dietary sodium restriction, orthostatism associated with sodium restriction, furosemide administration). The study revealed that each category of the present series of healthy and hypertensive individuals has an own temporal organization in the entire function of RAAS. This finding allowed to standardize the RIA reference indices as chronocorrelated intervals of normality and to establish the optimal criteria for the assessment of biochemical data and methodological study of hypertensive patients.
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