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  • Title: Assignment of the human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15.
    Author: Hildebrand CE, Gonzalez FJ, McBride OW, Nebert DW.
    Journal: Nucleic Acids Res; 1985 Mar 25; 13(6):2009-16. PubMed ID: 4000952.
    Abstract:
    The human 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 full-length cDNA has been recently isolated and sequenced [Jaiswal, A.K., Gonzalez, F.J. and Nebert, D.W. (1985) Science, in press]. A 1521-bp 5' DNA fragment representing almost all of the translating region was used to probe DNA from human, mouse, hamster, 53 human X mouse somatic cell hybrids, and 36 human X hamster somatic cell hybrids. These data indicate that the P1-450 gene resides on human chromosome 15. Knowledge of the chromosomal assignment of this gene should help in our understanding of its regulation and role in development and disease.
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