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  • Title: [Amine inhibition of serum-induced DNA synthesis in 3T3 and 3T6 cell cultures].
    Author: Nikol'skiĭ NN, Barkan RS, Bogdanova NP, Vinogradova NA, Sorokin AB.
    Journal: Tsitologiia; 1985 Apr; 27(4):451-7. PubMed ID: 4002341.
    Abstract:
    Several amines were shown to inhibit growth stimulation in quiescent confluent and sparse cultures of Swiss 3T3 and 3T6 cells by changing for a fresh medium containing 10-20% serum. Proliferation was inhibited by dansylcadaverine (0.1 mM), chloroquine (0.05 mM), 5-methoxytryptamine (0.1 mM), cystamine (0.1 mM), dimethylurea (100 mM), methylurea (100 mM), and in some experiments--by urea (100 mM). The inhibitory activity was not associated with a direct influence of amines on DNA synthesis or thymidine phosphorylation. The findings suggest that amines may influence the process of clustering of growth factor-receptor complexes, or the fusion of plasma membrane and intracellular vesicles containing some components required for cell proliferation.
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