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  • Title: [Neurologic manifestations and periaxonal demyelination in the central nervous system in different forms of experimental allergic encephalomyelitis].
    Author: Khizhniak MG, Zhitnukhin IuL.
    Journal: Zh Nevropatol Psikhiatr Im S S Korsakova; 1985; 85(4):545-9. PubMed ID: 4002946.
    Abstract:
    Comparing the neurological manifestations of experimentally-induced allergic encephalomyelitis (EAE) with the topography of developing demyelinization in the central nervous system of guinea-pigs allowed the authors to identify three forms of the diseases, namely spinal, cerebral and mixed. The spinal form caused by myelin decay in the lumbosacral segments of the spinal cord was expressed in the form of pareses and paralyses affecting the hind paws and also pelvic disorders. In the cerebral form, demyelinization was localized in the brain and was most frequently attended by vestibular disturbances. The mixed form characterized by pathological changes in both the spinal cord and brain was identified largely on the histological basis. In some animals (several of which died), EAE ran its course without apparent neurological symptoms and was identified only histologically.
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