These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Protein turnover in different types of skeletal muscle during experimental hyperthyroidism in rats.
    Author: Angerås U, Hasselgren PO.
    Journal: Acta Endocrinol (Copenh); 1985 May; 109(1):90-5. PubMed ID: 4003000.
    Abstract:
    Experimental hyperthyroidism was induced in rats by daily ip injection of triiodothyronine (T3; 100 micrograms/100 g body weight) during 3 or 10 days. Protein synthesis and degradation were measured in incubated soleus and extensor digitorum longus (EDL) muscles by determining rate of tyrosine incorporation into protein and release of tyrosine to the incubation medium respectively. Protein synthesis was unaffected by T3 administration during 3 or 10 days. Protein breakdown was significantly increased in soleus but unchanged in EDL in the 3-days experiment. Following administration of T3 for 10 days proteolysis was increased in both muscles. Weight of the soleus muscle was reduced after T3 for 3 days. After 10 days weight and protein content were reduced in both muscles. The study demonstrated that reduced muscle protein content following administration of T3 was the result of increased proteolysis, not decreased protein synthesis. The results further indicate that slow muscle (soleus) is more sensitive to the effects of thyroid hormone than fast muscle (EDL).
    [Abstract] [Full Text] [Related] [New Search]