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  • Title: Penbutolol and propranolol: a comparison of their effects on antipyrine clearance in man.
    Author: Bax ND, Jones RW, Lennard MS, Tucker GT, Woods HF.
    Journal: Br J Clin Pharmacol; 1985 May; 19(5):593-6. PubMed ID: 4005101.
    Abstract:
    The effects of two beta-adrenoceptor antagonists, penbutolol (administered on separate occasions as (+/-)- and (-)-forms) and propranolol, on the kinetics of antipyrine were studied in eight normal subjects. At the same degree of beta-adrenoceptor blockade, as assessed by the lowering of exercise tachycardia, propranolol decreased antipyrine clearance by 31 +/- 11 s.d.% (P less than 0.001) whereas neither of the two penbutolol formulations had a significant effect. The volume of distribution of antipyrine was unchanged following any of the beta-adrenoceptor antagonist treatments. The lack of effect of penbutolol on oxidative drug metabolism is not consistent with in vitro data suggesting a relationship between the lipid solubility of beta-adrenoceptor antagonists and inhibition of metabolism.
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