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  • Title: Serum lactate dehydrogenase isoenzyme-1 in children with yolk sac tumor.
    Author: Kinumaki H, Takeuchi H, Nakamura K, Ohmi K, Bessho F, Kobayashi N.
    Journal: Cancer; 1985 Jul 01; 56(1):178-81. PubMed ID: 4005788.
    Abstract:
    Although in recent years the evidence of an increase in serum lactate dehydrogenase isoenzyme-1 (LDH-1) in patients with germ cell tumor (GCT) has attracted attention, there have only been a few reports concerning yolk sac tumor (YST), which is a frequent type of GCT in childhood. Serum LDH isoenzymes were determined in eight children with YST, and an increase in LDH-1 was found in seven of them, excluding one in an early stage. On the basis of the findings of serial serum LDH-1 levels during treatment and of LDH isoenzyme pattern in tumor tissues, it is presumed that the increased serum LDH-1 is derived from tumor tissues. LDH-1 seems to be useful as a tumor marker, not specific for YST but associated with the whole spectrum of GCT, for monitoring of YST.
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