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  • Title: A mutagenic metabolite produced by Fusarium moniliforme isolated from Linxian county, China.
    Author: Cheng SJ, Jiang YZ, Li MH, Lo HZ.
    Journal: Carcinogenesis; 1985 Jun; 6(6):903-5. PubMed ID: 4006077.
    Abstract:
    Fusarin C, a fungal metabolite, was recently isolated and identified from corn meal inoculated with Fusarium moniliforme which was one of the most common fungi associated with corn in Linxian county, a high-incidence area of esophageal cancer. In the presence of S-9 mix, fusarin C significantly increased the number of revertants in Salmonella typhimurium TA 100, and induced SCE, micronuclei, chromosome aberrations and 6-TG resistant mutants in V79 cells. The toxic action of fusarin C on V79 cells was much stronger in the absence of S-9 mix. However, fusarin C did not show, at the largest concentration used, any significant mutagenic or clastogenic effect on the cells without the addition of S-9 mix. The possible relationship between the consumption of corn contaminated with F. moniliforme and the cause of esophageal cancer was discussed.
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