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  • Title: Hybridization with human cells corrects the elevated SCE frequency and BrdU hypersensitivity of hamster cell line EM9.
    Author: Ray JH, Louie E, German J.
    Journal: Cytogenet Cell Genet; 1985; 39(2):154-7. PubMed ID: 4006520.
    Abstract:
    Cells of the Chinese hamster line EM9 exhibit an elevated SCE frequency and a decreased proliferative response in bromodeoxyuridine (BrdU)-containing medium. Here, these phenotypic features were examined experimentally using polyethylene glycol fusion of EM9 and normal human cells. EM9/human hybrids exhibited both normal SCE frequencies and normal proliferative responses in BrdU-containing medium, suggesting that SCE elevation and BrdU hypersensitivity in EM9 have a common molecular basis.
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