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  • Title: Oncogenes and linkage groups: conservation during mammalian chromosome evolution.
    Author: Stallings RL, Munk AC, Longmire JL, Jett JH, Wilder ME, Siciliano MJ, Adair GM, Crawford BD.
    Journal: Chromosoma; 1985; 92(2):156-63. PubMed ID: 4006599.
    Abstract:
    Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS-all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years.
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