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  • Title: Neurochemical evidence for the release of acetylcholine from the guinea-pig ileum myenteric plexus by capsaicin.
    Author: Barthó L, Vizi ES.
    Journal: Eur J Pharmacol; 1985 Mar 26; 110(1):125-7. PubMed ID: 4007048.
    Abstract:
    Superfusion of the sensory stimulant drug capsaicin (3.3 microM) released [3H]acetylcholine from isolated myenteric plexus-longitudinal muscle strips of guinea-pig ileum, preincubated with [3H]choline. This effect was prevented by tetrodotoxin. There was a fast tachyphylaxis to the effect of capsaicin. It is suggested that capsaicin-sensitive nerve endings capable of activating intrinsic cholinergic neurones are situated in the myenteric plexus of the guinea-pig ileum.
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