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  • Title: Amides of N-phenyl benzonorbornen-2-endo-amine with hypotensive and other activities.
    Author: Longobardi M, Schenone P, Bargagna A, Berrino L, Matera C, Marmo E.
    Journal: Farmaco Sci; 1985 Mar; 40(3):152-61. PubMed ID: 4007149.
    Abstract:
    The synthesis of two series of amides and glycinamides starting from N-phenyl benzonorbornen-2-endo-amine, prepared from benzonorbornen-2-one via sodium borohydride reduction of its N-phenyl imine, is described. Some amides showed a remarkable hypotensive activity in rats, whereas amides and glycinamides usually exhibited a moderate infiltration anesthesia in mice. Effects on heart rate in rats and antiarrhythmic activity in mice are also reported.
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