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  • Title: [Synthesis and antiinflammatory activity of various 1,4-benzothiazine derivatives].
    Author: Trapani G, Reho A, Morlacchi F, Latrofa A, Marchini P, Venturi F, Cantalamessa F.
    Journal: Farmaco Sci; 1985 May; 40(5):369-76. PubMed ID: 4007156.
    Abstract:
    A new series of dihydro-4H-1,4-benzothiazine derivatives was prepared. These compounds were obtained by reductive N-alkylation reaction with sodium borohydride in acetic acid of the corresponding 4H-1,4-benzothiazine. Some of the latter compounds were synthesized by a new synthetic method employing 2-aminobenzenethiol and alkynes as starting material. Preliminary pharmacological data on the antiinflammatory activity of these compounds by using carrageenin paw edema assay are reported.
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