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  • Title: Effect of the inhibitory material from male genital tract on natural killing activities.
    Author: Marcus ZH, Dondero F, Lunenfeld B, Lewin LM.
    Journal: Immunol Lett; 1985; 10(1):1-5. PubMed ID: 4007959.
    Abstract:
    A male inhibitory material (HuSePl-Frl) was separated from normal human seminal plasma by gel filtration on Sephadex G-100. This material has high avidity for cell membranes of human red blood cells (RBC). In vitro, PHA-M-induced blast transformation of human lymphocytes is inhibited by small quantities of HuSePl-Frl. This inhibition was also evident when RBC coated with HuSePl-Frl is added to mitogen stimulated lymphocytes in cultures. Small quantities of HuSePl-Frl are inhibitory to natural killer (NK) cell activation. The modulating role of the HuSePl-Frl in preventing the spermatozoal rejection during fertilization is discussed.
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