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  • Title: Isotypic and idiotypic characterization of anti-bee venom phospholipase A2 antibodies.
    Author: Wetterwald A, Skvaril F, Müller U, Blaser K.
    Journal: Int Arch Allergy Appl Immunol; 1985; 77(1-2):195-7. PubMed ID: 4008074.
    Abstract:
    It was shown that anti-bee venom phospholipase A2 antibodies (anti-PLA) of bee keepers belong mainly to the IgG4 class. Furthermore anti-PLA of different individuals are idiotypically related to each other. This was shown by the binding of heterologous antiidiotypic antibodies, produced against anti-PLA IgG from single donors, to anti-PLA F(ab')2 of different individuals. Therefore, the anti-PLA response provides a human model to study the idiotypic regulation of isotypes in a defined system.
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