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  • Title: Macrophage activation by MDP bound to neoglycoproteins: metastasis eradication in mice.
    Author: Roche AC, Bailly P, Monsigny M.
    Journal: Invasion Metastasis; 1985; 5(4):218-32. PubMed ID: 4008192.
    Abstract:
    Neoglycoproteins, which bind to membrane lectins of macrophages and are selectively endocytosed, were substituted with N-acetyl-muramyldipeptide (MDP). Such MDP-conjugates are shown to be able to induce macrophage tumoricity both in vitro and in vivo in a way much more efficient than free MDP does. These MDP-neoglycoprotein conjugates are shown to protect mice against metastatic growth.
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